A Gracious Tone. Your resignation letter is not the time to air grudges, take passive_aggressive shots, or otherwise be unpleasant. Regardless of how you feel about your (soon to be former) job or your boss, this letter should be an exercise in professionalism and graciousness. An excellent way to do that is to say a simple "thank you." Even if you hated your job, you got something from it at some point. Focus on that positive bit if you need to.
Also think about your relationship with your manager. Would he or she have reason to think that you'll waste your last two weeks or distract your co_workers instead of doing what you can to make the transition seamless? If so, you may be asked to cut your two weeks short.