Acceptance With Grace. The best_case scenario__and honestly, the most common reaction__is that your boss will accept your resignation with understanding and sincere congratulations. Your manager will be happy to see that you're advancing your career and moving on to something bigger and better.
Prepare for It. Your best option in this scenario is to accept it with dignity and make sure you're ready to leave the office for good when you turn in your resignation letter, whether that means gathering up your personal items or making sure you've collected the names and contact information for the teammates and clients you'd like to stay in touch with.