You'll have plenty of time to vent personally about your work grievances as you leave, but really, you stand to gain nothing by putting negativity into your resignation letter. And unless you're leaving the state and your current industry, you always run the risk of running into the same people later on. So you're far better off taking the high road and making sure your exit is a classy one.
Acceptance With Grace. The best_case scenario__and honestly, the most common reaction__is that your boss will accept your resignation with understanding and sincere congratulations. Your manager will be happy to see that you're advancing your career and moving on to something bigger and better.