Spot the Signs. The most obvious sign that you'll receive this reaction is if you haven't had a healthy relationship with your manager in the past. Maybe you continually challenged his ideas, and he took that as a sign of disrespect. Or, maybe she always made unreasonable demands, and you were never able to see eye_to_eye on your to_do list. Or perhaps his moods were completely unpredictable. In any case, if your relationship has been strained, you may receive a less_than_ideal response to your two weeks' notice.
Acceptance With Displeasure. It's possible that your boss won't take immediate action like the reaction above__but will make it clear that he or she isn't exactly happy about your resignation. Maybe, for example, she'll mutter a curt, "Thank you for letting me know," followed by two weeks of obvious displeasure or denial that you're leaving__through gruff comments ("You know, you're really leaving us in the lurch") or a refusal to interact with you more than absolutely necessary.