Turning in your two weeks notice can be terrifying__because no matter how well you think you know your supervisor, you can never be 100% sure of his or her reaction. Will he be furious and insist on walking you out the door immediately? Will she beg you to stay, enticing you with an enormous raise? Or will he be completely civil and wish you the best of luck?
Breaking up is hard to do, but pouring your heart out on paper is rather awkward. There is really no need for any other information in your resignation letter (including a reason __ which is completely optional). No effusive template and formatting effort is required. This is not a letter that is going to be hanging on anyone's wall, and it probably won't even be filed away!