A Professional Greeting. Your letter should be addressed to your boss. There's a good chance that this letter will merely end up in a file in HR, but it starts with your boss. Assuming this is someone with whom you work reasonably close with on a daily basis, it doesn't have to be super stiff and formal. Specific and professional is the right tone here.
Or meet up with said colleagues at an industry event, because the world is awkwardly small. So it's in your best interest to make sure that your resignation letter is clear, concise, and polite. Here are some best practices you can follow to make your big exit a professional one.