Prepare for It. This one is easy. All you have to do is smile and say "Thank you so much for your support. I've enjoyed my time here and I've learned a lot from you. Let me know what I can do to make the transition easier." Are you always going to get reaction number five? Probably not. But if you look for the signs, you can likely anticipate your boss' response, go into the conversation prepared, and come out stronger on the other side. Then, you can breathe a sign of relief and start looking forward to starting your new position.
Basic of a Resignation Letter. There's no need to sugarcoat or get creative in the beginning; just state the position you're resigning from and the effective date. While you probably shared with your boss your reasons for leaving, you don't need to describe them here__keeping it simple is perfectly fine.