Prepare for It. Your best option in this scenario is to accept it with dignity and make sure you're ready to leave the office for good when you turn in your resignation letter, whether that means gathering up your personal items or making sure you've collected the names and contact information for the teammates and clients you'd like to stay in touch with.
Turning in your two weeks notice can be terrifying__because no matter how well you think you know your supervisor, you can never be 100% sure of his or her reaction. Will he be furious and insist on walking you out the door immediately? Will she beg you to stay, enticing you with an enormous raise? Or will he be completely civil and wish you the best of luck?