Acceptance With Displeasure. It's possible that your boss won't take immediate action like the reaction above__but will make it clear that he or she isn't exactly happy about your resignation. Maybe, for example, she'll mutter a curt, "Thank you for letting me know," followed by two weeks of obvious displeasure or denial that you're leaving__through gruff comments ("You know, you're really leaving us in the lurch") or a refusal to interact with you more than absolutely necessary.
However, at most companies, there's no formal requirement that you do so. Most employment in the United States is called "at will", which means that your current employer can fire you at any time and for any reason (except those that are prohibited under law).