Spot the Signs. Do you have a good relationship with your manager? Is he or she relatively reasonable? Do you have regular one_on_ones where you talk about your career goals and growth? If so, it's likely that your boss will accept your resignation with grace, help develop a plan of action for your last two weeks, and maybe even attend your farewell happy hour.
Or meet up with said colleagues at an industry event, because the world is awkwardly small. So it's in your best interest to make sure that your resignation letter is clear, concise, and polite. Here are some best practices you can follow to make your big exit a professional one.