And sure, this could be an email (all of the same principles would apply), but a letter makes things official in every sense. It also gives you a prop to take along to the face_to_face meeting with your boss, when you let him or her know that you're leaving.
Prepare for It. In this case, all you can do is politely deliver your resignation, then strive to make the transition as easy as possible for your team. Your manager may not have the ideal reaction to your news__and your workplace may not be the most pleasant environment for the next two weeks__but to avoid burning bridges, it's best to work through it with a positive attitude.