Acceptance With Grace. The best_case scenario__and honestly, the most common reaction__is that your boss will accept your resignation with understanding and sincere congratulations. Your manager will be happy to see that you're advancing your career and moving on to something bigger and better.
On the flip side, if you loved your job, your coworkers, your boss, the cappuccino machine, everything about the place, don't write page upon page waxing rhapsodic about all that you're giving up by leaving. A brief, heartfelt compliment to the company, or a thank you, is fine.