Acceptance With Displeasure. It's possible that your boss won't take immediate action like the reaction above__but will make it clear that he or she isn't exactly happy about your resignation. Maybe, for example, she'll mutter a curt, "Thank you for letting me know," followed by two weeks of obvious displeasure or denial that you're leaving__through gruff comments ("You know, you're really leaving us in the lurch") or a refusal to interact with you more than absolutely necessary.
Prepare for It. In this case, all you can do is politely deliver your resignation, then strive to make the transition as easy as possible for your team. Your manager may not have the ideal reaction to your news__and your workplace may not be the most pleasant environment for the next two weeks__but to avoid burning bridges, it's best to work through it with a positive attitude.