Prepare for It. In this case, all you can do is politely deliver your resignation, then strive to make the transition as easy as possible for your team. Your manager may not have the ideal reaction to your news__and your workplace may not be the most pleasant environment for the next two weeks__but to avoid burning bridges, it's best to work through it with a positive attitude.
Turning in your two weeks notice can be terrifying__because no matter how well you think you know your supervisor, you can never be 100% sure of his or her reaction. Will he be furious and insist on walking you out the door immediately? Will she beg you to stay, enticing you with an enormous raise? Or will he be completely civil and wish you the best of luck?