Acceptance With Displeasure. It's possible that your boss won't take immediate action like the reaction above__but will make it clear that he or she isn't exactly happy about your resignation. Maybe, for example, she'll mutter a curt, "Thank you for letting me know," followed by two weeks of obvious displeasure or denial that you're leaving__through gruff comments ("You know, you're really leaving us in the lurch") or a refusal to interact with you more than absolutely necessary.
What Else Should I Do When Resigning? First, out of respect and common courtesy, you would ideally tell your manager in person that you are resigning. If you can't wait for that or work remotely or some other complication prevents that, the telephone is the next best option. You can choose to follow up or accompany that discussion with a formal letter of resignation afterwards, but it would be a rare workplace that would require that formality.