Spot the Signs. The most obvious sign that you'll receive this reaction is if you haven't had a healthy relationship with your manager in the past. Maybe you continually challenged his ideas, and he took that as a sign of disrespect. Or, maybe she always made unreasonable demands, and you were never able to see eye_to_eye on your to_do list. Or perhaps his moods were completely unpredictable. In any case, if your relationship has been strained, you may receive a less_than_ideal response to your two weeks' notice.
Acceptance With Grace. The best_case scenario__and honestly, the most common reaction__is that your boss will accept your resignation with understanding and sincere congratulations. Your manager will be happy to see that you're advancing your career and moving on to something bigger and better.