Spot the Signs. Do you have a good relationship with your manager? Is he or she relatively reasonable? Do you have regular one_on_ones where you talk about your career goals and growth? If so, it's likely that your boss will accept your resignation with grace, help develop a plan of action for your last two weeks, and maybe even attend your farewell happy hour.
Even those that require you give a certain amount of "notice" before you quit your current job (two_week notice is standard) often may not provide any formal requirement that you do so by writing a letter of resignation or explain in detail why you're leaving.