What Else Should I Do When Resigning? First, out of respect and common courtesy, you would ideally tell your manager in person that you are resigning. If you can't wait for that or work remotely or some other complication prevents that, the telephone is the next best option. You can choose to follow up or accompany that discussion with a formal letter of resignation afterwards, but it would be a rare workplace that would require that formality.
A Professional Greeting. Your letter should be addressed to your boss. There's a good chance that this letter will merely end up in a file in HR, but it starts with your boss. Assuming this is someone with whom you work reasonably close with on a daily basis, it doesn't have to be super stiff and formal. Specific and professional is the right tone here.