Spot the Signs. The most obvious sign that you'll receive this reaction is if you haven't had a healthy relationship with your manager in the past. Maybe you continually challenged his ideas, and he took that as a sign of disrespect. Or, maybe she always made unreasonable demands, and you were never able to see eye_to_eye on your to_do list. Or perhaps his moods were completely unpredictable. In any case, if your relationship has been strained, you may receive a less_than_ideal response to your two weeks' notice.
After that, you're ready to close out your letter and move on. The basic closings are fine here__again, you don't need to go overly sentimental or formal, but you should also write as if it will be read by anyone at the company. And with that signing flourish, you're done! You've resigned, and you're ready for your exciting new job.